Functional dissection of complex trait variants at single-nucleotide resolution

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Imagine a vast shopping mall parking lot with thousands of individual parking spots and internal lanes (representing road segments within a cluster). No matter how complex it is inside, there are usually only a few key exits to the main roads. Our goal was to identify these natural "exits" for each map cluster. For instance, the complex road network around Amsterdam Airport Schiphol (see on OpenStreetMap) has many internal roads but limited primary access points.

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Some analyse chemical bonds to compare them against genuine honey samples. Others analyse isotopes to determine where a product likely originated.